Document Detail

Anorectal function following colo-anal sleeve anastomosis for chronic radiation injury to the rectum.
MedLine Citation:
PMID:  3697659     Owner:  NLM     Status:  MEDLINE    
Anorectal manometry and electrophysiological studies of the pelvic floor were performed in eight patients who had undergone anterior resection of the rectum with mucosal proctectomy and colo-anal sleeve anastomosis for radiation rectal injury. There is a severe reduction in the compliance of the neorectum and in the maximal tolerable volume. Maximum basal anal canal pressure and physiological sphincter length are also significantly reduced although the 'squeeze' pressure of the external anal sphincter and the latency of the pudendo-anal reflex were unaffected. Four patients had an absent rectosphincteric reflex, four patients involuntarily expelled the test balloon at the maximal tolerable volume during a proctometrogram and four patients demonstrated increased EMG activity of the pelvic floor on straining and on rectal distension. These abnormalities help to explain many of the patients' symptoms. Histological abnormalities of the myenteric plexus were a prominent feature in all the excised specimens and may be responsible for some of the functional abnormalities.
J S Varma; A N Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  73     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-23     Completed Date:  1986-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  AIM; IM    
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MeSH Terms
Anal Canal / physiopathology,  surgery*
Chronic Disease
Colon / surgery*
Middle Aged
Myenteric Plexus / pathology
Radiation Injuries / surgery*
Rectum / physiopathology*,  radiation effects
Reflex / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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