Document Detail

Anorectal function after three- versus two-dimensional radiation therapy for carcinoma of the prostate.
MedLine Citation:
PMID:  18571336     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the effects of (three-dimensional) 3D vs. two-dimensional (2D) radiation therapy (RT) for carcinoma of the prostate on the prevalence and pathophysiology of anorectal dysfunction. METHODS AND MATERIALS: Anorectal symptoms, motility, sensory function, and anal sphincter morphology were evaluated before and up to 2 years after randomly assigned hypofractionated vs. conventionally fractionated RT in 67 patients (median age, 69 years; range, 54-82 years) with localized prostate carcinoma, using either a 3D (n = 29) or 2D (n = 38) treatment technique. RESULTS: Anorectal symptoms increased 4 to 6 weeks after RT and persisted in both patient groups. At 2 years, abnormalities included increased stool frequency (55% vs. 53%, p = NS), urgency of defecation (72% vs. 47%, p < 0.05), fecal incontinence (28% vs. 26%, p = NS), and rectal bleeding (38% and 42%, p = NS). Anorectal motility and sensory function deteriorated after RT in both groups with reductions in basal anal pressures, anal pressures in response to squeeze, rectal compliance, and rectal volumes associated with the desire to defecate. External but not internal sphincter thickness changed in the treatment groups although in different directions. However no differences in motility or sensory function were detected between the groups. Baseline anorectal motility but not treatment technique and the hypofracionated schedule were of independent prognostic significance for anorectal motor dysfunction and rectal bleeding respectively at 2 years. CONCLUSION: The prevalence and pathophysiology of anorectal dysfunction 2 years after RT for prostate carcinoma was largely independent of the treatment techniques used in this study.
Eric K Yeoh; Richard H Holloway; Robert J Fraser; Rochelle Botten; Addolorata Di Matteo; James W Moore; Mark N Schoeman; Dylan L Bartholomeusz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-06-18
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  73     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide SA, Australia.
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MeSH Terms
Aged, 80 and over
Anus Diseases / diagnosis,  epidemiology
Australia / epidemiology
Middle Aged
Prostatic Neoplasms / epidemiology*,  radiotherapy*
Radiation Injuries / diagnosis,  epidemiology*
Radiotherapy, Conformal / methods*,  statistics & numerical data*
Rectal Diseases / diagnosis,  epidemiology*
Risk Assessment / methods*
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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