| Anorectal function and visceral hypersensitivity in celiac disease. | |
| | |
MedLine Citation:
|
PMID: 20562634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate anorectal function and rectal sensitivity thresholds in patients with celiac disease (CD). METHODS: In 25 unselected patients with CD (16 female, 9 male; mean age 45, range 24 to 75 y) and 20 controls (12 female, 8 male; mean age 41, range 20 to 65 y) anorectal manometry and rectal balloon distension test were conducted using a 4 lumen water perfused catheter with a polyethylene balloon (Zinectics Manometric Catheter, Medtronic). RESULTS: In celiac patients the maximal anal resting pressure, reflecting the internal anal sphincter function, was significantly higher than that in the controls: 87.8±21.7 mm Hg versus 66.7±15.2 mm Hg (P<0.001). There were no considerable differences between both the groups neither in the maximal anal squeeze nor in the cough pressures. Celiac patients had significantly lower first sensation threshold: 25.6±10.8 mL versus 37.5±12.5 mL (P<0.05). Visceral hypersensitivity (rectal pain/discomfort threshold ≤100 mL) was observed in 36% of celiac patients and in none of the controls (P<0.01). CONCLUSIONS: The increased anal resting pressure and rectal hypersensitivity are observed in CD. Disturbances in gastrointestinal motility and visceral perception in the course of CD may occur at different levels of the brain-gut axis including direct changes in the enteric nervous system. |
| | |
Authors:
|
Agata Mulak; Ewa Waszczuk; Leszek Paradowski |
Related Documents
:
|
2055144 - Colonic motility: electric and manometric description of mass movement. 1254134 - Manometric studies on the human pyloric sphincter. effect of cigarette smoking, metoclo... 17252464 - An endoscopically implantable device stimulates the lower esophageal sphincter on deman... 1568584 - The effect of the cholecystokinin receptor antagonist mk-329 on meal-stimulated pancrea... 16408054 - High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. 15630604 - Behavior of arthroscopic irrigation systems. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 44 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2010 Nov-Dec |
Date Detail:
|
Created Date: 2010-10-18 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: e249-52 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anal Canal / innervation* Balloon Dilation Case-Control Studies Celiac Disease / complications*, physiopathology Enteric Nervous System / physiopathology Female Humans Hyperalgesia / etiology*, physiopathology Male Manometry Middle Aged Pain Measurement Pressure Rectum / innervation* Sensory Thresholds Viscera / innervation* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel food: a new reality in food ingredient.
Next Document: Sneezing-associated Rectus Sheath Hematoma After Percutaneous Liver Biospy.