Document Detail


Anomalously high excretion of Pu in urine following inhalation of plutonium nitrate?
MedLine Citation:
PMID:  14526978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study of the biokinetics of inhaled plutonium nitrate in two volunteers has been carried out. Low doses (approximately 80 microSv) were achievable because tracers of high isotopic purity were used: 237Pu (measurable by X ray spectrometry) and 244Pu (measurable by accelerator mass spectrometry). Lung retention, amount in blood, uptake to the liver and skeleton, and urinary and faecal excretion were measured. The measured urinary excretion rates are about a factor of three higher than those predicted from urine excretion data measured following intravenous injection of plutonium to the same volunteers. If similar biokinetic behaviour occurs in workers exposed to plutonium nitrate, intakes by inhalation and corresponding committed doses assessed by urine bioassay could be consistently overestimated by a similar factor.
Authors:
G Etherington; G N Stradling; A Hodgson; L K Fifield
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Publication Detail:
Type:  Case Reports; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiation protection dosimetry     Volume:  105     ISSN:  0144-8420     ISO Abbreviation:  Radiat Prot Dosimetry     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-06     Completed Date:  2003-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109958     Medline TA:  Radiat Prot Dosimetry     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
Affiliation:
National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK. GEORGE.ETHERINGTON@NRPB.ORG
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Humans
Incidental Findings
Liver / metabolism*
Lung / metabolism*
Male
Nitrates / administration & dosage,  blood,  pharmacokinetics*,  urine*
Plutonium / administration & dosage,  blood,  pharmacokinetics*,  urine*
Radiation Dosage
Radiometry / methods*
Chemical
Reg. No./Substance:
0/Nitrates; 14913-29-2/plutonium nitrate; 7440-07-5/Plutonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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