| Anomalous phospholipid n-6 polyunsaturated fatty acid composition in idiopathic calcium nephrolithiasis. | |
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MedLine Citation:
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PMID: 8724896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anomalies in the erythrocyte transport of anions and cations have been described in idiopathic calcium oxalate nephrolithiasis and seem to play a pathogenetic role in this disease. In consideration of the hypothesis that the complex array of ion flux cell abnormalities is an epiphenomenon of an anomaly in the composition of cell membranes, this study investigated cell-membrane lipid composition. In idiopathic calcium oxalate renal stone formers, in which ion transport abnormalities were present, and in healthy control subjects, plasma and erythrocyte membrane lipid composition, the erythrocyte oxalate exchange, and Na/K/2Cl cotransport activity were evaluated. Furthermore, in stone formers, the effect of a 30-day fish-oil diet supplementation on plasma lipids, erythrocyte oxalate exchange, oxaluria, and calciuria was investigated. The effect of archidonic acid released by phospholipase A2 on anion-carrier phosphorylation and activity in erythrocytes was evaluated as well. Patients had a lower content of linoleic and higher concentration of archidonic acids in both plasma and erythrocyte membrane phospholipids, and an increased archidonic/linoleic acid ratio. The archidonic acid level correlated with the erythrocyte oxalate exchange and sodium cotransport activity. Fish-oil supplementation lowered calcium and oxalate urine excretion, and normalized the erythrocyte oxalate exchange. Phospholipase A2 increased the erythrocyte anion-carrier protein phosphorylation and the oxalate exchange. This study shows that idiopathic calcium nephrolithiasis in the patient group reported here is characterized by a systemic defect in phospholipid archidonic acid levels that might provide an answer to the link between genetic background, dietary habits, and renal lithiasis. |
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Authors:
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B Baggio; G Gambaro; S Zambon; F Marchini; A Bassi; L Bordin; G Clari; E Manzato |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 7 ISSN: 1046-6673 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-29 Completed Date: 1996-10-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 613-20 Citation Subset: IM |
Affiliation:
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Institute of Internal Medicine, School of Medicine, University of Padova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arachidonic Acid / metabolism Biological Transport Calcium Oxalate / metabolism*, urine Chlorides / metabolism Dietary Fats, Unsaturated / metabolism* Erythrocyte Membrane / metabolism* Fatty Acids, Omega-6 Fatty Acids, Unsaturated / analysis*, blood Female Fish Oils / administration & dosage, pharmacology Humans Kidney Calculi / blood, etiology* Middle Aged Phospholipases A / metabolism Phospholipases A2 Phospholipids / blood, chemistry* Potassium / metabolism Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Phospholipids; 25454-23-3/Calcium Oxalate; 506-32-1/Arachidonic Acid; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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