| Anomalous spatial redistribution of competing bacteria under starvation conditions. | |
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MedLine Citation:
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PMID: 21317322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial cells evolved under prolonged stress often have a growth advantage in stationary phase (GASP); we expect GASP cells to maintain a proliferative state and dominate wild-type cells during starvation, especially when nutrients are limited and the medium has been conditioned. However, when we compete GASP mutants against wild-type cells in a chain of microfluidic microhabitat patches (MHPs) with alternating nutrient-rich and nutrient-limited regions, we observe the reverse effect: wild-type cells achieve maximum relative density under nutrient-limited conditions, while GASP cells dominate nutrient-rich regions. We explain this surprising observation in terms of ideal free distributions, where we show that wild-type cells maximize their fitness at high cell density by redistributing themselves to sparsely populated MHPs. At the microscopic level, we describe how biofilm formation also contributes to the population redistribution. We conclude by discussing the implications of these results for social interactions of more complex organisms. |
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Authors:
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Guillaume Lambert; David Liao; Saurabh Vyawahare; Robert H Austin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-02-11 |
Journal Detail:
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Title: Journal of bacteriology Volume: 193 ISSN: 1098-5530 ISO Abbreviation: J. Bacteriol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-08 Completed Date: 2011-06-06 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: United States |
Other Details:
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Languages: eng Pagination: 1878-83 Citation Subset: IM |
Affiliation:
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Department of Physics, Princeton University, Princeton, NJ 08544, USA. glambert@princeton.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Culture Media
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chemistry Escherichia coli / growth & development*, metabolism* Microbial Interactions* Phenotype Stress, Physiological* |
| Grant Support | |
ID/Acronym/Agency:
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U54CA143803/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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