Document Detail


Anomalous spatial redistribution of competing bacteria under starvation conditions.
MedLine Citation:
PMID:  21317322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacterial cells evolved under prolonged stress often have a growth advantage in stationary phase (GASP); we expect GASP cells to maintain a proliferative state and dominate wild-type cells during starvation, especially when nutrients are limited and the medium has been conditioned. However, when we compete GASP mutants against wild-type cells in a chain of microfluidic microhabitat patches (MHPs) with alternating nutrient-rich and nutrient-limited regions, we observe the reverse effect: wild-type cells achieve maximum relative density under nutrient-limited conditions, while GASP cells dominate nutrient-rich regions. We explain this surprising observation in terms of ideal free distributions, where we show that wild-type cells maximize their fitness at high cell density by redistributing themselves to sparsely populated MHPs. At the microscopic level, we describe how biofilm formation also contributes to the population redistribution. We conclude by discussing the implications of these results for social interactions of more complex organisms.
Authors:
Guillaume Lambert; David Liao; Saurabh Vyawahare; Robert H Austin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-02-11
Journal Detail:
Title:  Journal of bacteriology     Volume:  193     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-08     Completed Date:  2011-06-06     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1878-83     Citation Subset:  IM    
Affiliation:
Department of Physics, Princeton University, Princeton, NJ 08544, USA. glambert@princeton.edu
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MeSH Terms
Descriptor/Qualifier:
Culture Media / chemistry
Escherichia coli / growth & development*,  metabolism*
Microbial Interactions*
Phenotype
Stress, Physiological*
Grant Support
ID/Acronym/Agency:
U54CA143803/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media
Comments/Corrections

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