Document Detail

Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy.
MedLine Citation:
PMID:  18768734     Owner:  NLM     Status:  MEDLINE    
The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved (1)H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.
H-S Liu; H-W Chung; C-J Juan; S-Y Tsai; C-Y Wang; C-C Chan; G-S Huang; M-C Chou; C-S Lee; C-W Ko; N-Y Cho; C-Y Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-03
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-09     Completed Date:  2008-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1644-8     Citation Subset:  IM    
Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
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MeSH Terms
Alanine / metabolism
Amino Acids / metabolism*
Biological Markers / metabolism
Brain Abscess / diagnosis*
Image Processing, Computer-Assisted*
Isoleucine / metabolism
Lactic Acid / metabolism
Leucine / metabolism
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy / methods*
Phantoms, Imaging*
Sensitivity and Specificity
Valine / metabolism
Young Adult
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 50-21-5/Lactic Acid; 56-41-7/Alanine; 61-90-5/Leucine; 7004-03-7/Valine; 73-32-5/Isoleucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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