Document Detail


Anodal transcranial direct current stimulation modulates GABAB-related intracortical inhibition in the M1 of healthy individuals.
MedLine Citation:
PMID:  23196416     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
It is known that transcranial direct current stimulation (tDCS) can induce polarity-specific shifts in brain excitability of the primary motor cortex (M1) with anodal tDCS enhancing and cathodal tDCS reducing cortical excitability. However, less is known about its impact on specific intracortical inhibitory mechanisms, such as γ-aminobutyric acid B (GABAB)-mediated inhibition. Consequently, the aim of the present study was to assess the impact of anodal and cathodal tDCS on M1 intracortical inhibition in healthy individuals. Long-interval intracortical inhibition (LICI) and cortical silent period (CSP) duration, both presumably mediated by GABAB receptors, were assessed using transcranial magnetic stimulation immediately before and after a 20 min session of tDCS over the left M1. Anodal tDCS significantly enhanced motor evoked potential size and reduced CSP duration, whereas it had no effect on LICI. Cathodal stimulation did not significantly modulate motor evoked potential size, CSP duration or LICI. This study provides evidence that anodal tDCS, presumably by synaptic plasticity mechanisms, has a direct effect on GABAB-meditated inhibition assessed by the CSP, but not by LICI. Our results further suggest that CSP and LICI probe distinct intracortical inhibitory mechanisms as they are differentially modulated by anodal tDCS. Finally, these data may have clinical value in patients in whom a pathological increase in CSP duration is present, such as schizophrenia.
Authors:
Sara Tremblay; Vincent Beaulé; Jean-François Lepage; Hugo Théoret
Related Documents :
22999736 - Self-regulation of brain oscillations as a treatment for aberrant brain connections in ...
22951276 - Non-invasive brain stimulation in the functional evaluation of alcohol effects and in t...
21977016 - Modeling the connectome of a simple spinal cord.
21508086 - Visual and auditory perceptual rivalry in migraine.
21059746 - Involvement of the subthalamic nucleus in impulse control disorders associated with par...
11092056 - Pathophysiology of brain insult. therapeutic implications with the lund concept.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  24     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Affiliation:
aPsychology department, University of Montreal bResearch Center, Sainte-Justine Hospital, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Activation of the left superior temporal gyrus of musicians by music-derived sounds.
Next Document:  Patient-ventilator interaction in ARDS patients with extremely low compliance undergoing ECMO: a nov...