| Ano-rectal motility responses to pelvic, hypogastric and pudendal nerve stimulation in the Göttingen minipig. | |
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MedLine Citation:
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PMID: 16420294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of efferent stimulation of the pelvic (PN), hypogastric (HGN) and pudendal (PuN) nerves on ano-rectal motility in Göttingen minipigs using an impedance planimetry probe. Changes in the rectal cross-sectional area (CSA) at five axial positions and pressures in the rectum and anal canal were investigated simultaneously. Pelvic nerve stimulation elicited a CSA decrease in the proximal part of the rectum and a simultaneous CSA increase in its distal part. Anal pressure also decreased. Hypogastric nerve and PuN stimulation elicited an increase in anal pressure, but no rectal response. Severing the HGN produced a persistent reduction in resting anal pressure, but no change was observed when the PN and the PuN were severed. Stimulation of the distal part of all three nerves produced a persistent response. Administration of phentolamine and pancouronium eliminated the response to stimulation of the HGN and the PuN, respectively. CONCLUSION: Rectal responses to PN stimulation vary more than previously suggested. The HGN has an excitatory effect on the internal anal sphincter, and the PuN on the external anal sphincter. However, the PuN plays no major role in maintaining basal anal pressure. |
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Authors:
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I S Andersen; S Buntzen; N J M Rijkhoff; A L Dalmose; J C Djurhuus; S Laurberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 18 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-19 Completed Date: 2006-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 153-61 Citation Subset: IM |
Affiliation:
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Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark. inge.scheel@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anal Canal
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innervation*,
physiology* Animals Electric Impedance Female Gastrointestinal Motility / physiology* Hypogastric Plexus Rectum / innervation*, physiology* Swine Swine, Miniature |
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