Document Detail


Annonaceous acetogenins: recent progress.
MedLine Citation:
PMID:  10096871     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.
Authors:
F Q Alali; X X Liu; J L McLaughlin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of natural products     Volume:  62     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  504-40     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / biosynthesis,  chemistry,  pharmacology*
Drug Resistance, Microbial
Drug Resistance, Multiple
Furans / chemistry,  metabolism,  pharmacology*
Humans
Lactones / chemistry,  metabolism,  pharmacology*
Pesticides / chemistry,  pharmacology*
Plants, Medicinal / chemistry*
Grant Support
ID/Acronym/Agency:
CA 30909/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Furans; 0/Lactones; 0/Pesticides; 0/isomurisolenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A novel extracellular diterpenoid with antibacterial activity from the cyanobacterium Nostoc commune...
Next Document:  DNA-protein cooperative binding through variable-range elastic coupling.