Document Detail


Annexin A5 levels in midtrimester amniotic fluid: association with intrauterine growth restriction.
MedLine Citation:
PMID:  16579937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine whether amniotic fluid levels of annexin A5 (AF-AnxA5) may be associated with intrauterine growth restriction (IUGR). STUDY DESIGN: Amniotic fluid was obtained in a cohort of pregnant patients (n = 172) undergoing amniocentesis at 15 to 24 weeks' gestation and annexin A5 (AnxA5) levels were determined with enzyme-linked immunosorbent assay (ELISA). Patients who developed IUGR were compared with the remainder of the cohort. RESULTS: AF-AnxA5 levels significantly increased through gestation (P = .003). The mean level of AF-AnxA5 in IUGR patients (n = 15) was significantly higher (P = .028) than in the remainder of the cohort (n = 130). Elevated AF-AnxA5 > 20 ng/mL was associated with a relative risk of 3.5 for the development of IUGR (P = .023). CONCLUSION: AnxA5 is present in amniotic fluid and increases through gestation from 15 to 24 weeks. Elevated AF-AnxA5 levels were present in patients who developed IUGR. AF-AnxA5 may be a useful marker for identifying pregnancy abnormalities.
Authors:
Peter Van Eerden; Xiao-Xuan Wu; Cynthia Chazotte; Jacob H Rand
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-03-30
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  194     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-06-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1371-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics & Gynecology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis
Amniotic Fluid / metabolism*
Annexin A5 / metabolism*
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Fetal Growth Retardation / etiology,  metabolism*
Gestational Age
Humans
Linear Models
Pregnancy
Pregnancy Trimester, Second*
Risk
Grant Support
ID/Acronym/Agency:
HL-61331/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Annexin A5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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