Document Detail

Ankylosing spondylitis in women.
MedLine Citation:
PMID:  6245628     Owner:  NLM     Status:  MEDLINE    
Although ankylosing spondylitis (AS) has been considered rare in women, we believe that its incidence is underestimated. In our case studies of 12 women with AS the characteristic clinical features of the disease included onset before the age of 30 (12 patients); night pain and morning stiffness (12 patients); intermittent, migratory joint pain (9 patients); and history of uveitis (2 patients). Spine mobility was decreased in all patients. Sacroiliac (SI) (8 patients) and circumthoracic (5 patients) tenderness were common findings. If these pertinent clues are present, further diagnostic studies are indicated. Histocompatibility testing for the HLA-B27 antigen, which is reported to be present in over 90% of patients with AS, is useful in detecting early and mild forms of the disease. We found the antigen in 10 of 11 patients tested. Radioisotope (RI) scanning can show early inflammation of the SI joints long before changes are evident on standard roentgenograms: In 3 cases, SI films were reported as normal but RI scans revealed abnormal uptake and ratios. Early detection of AS prevents inappropriate treatment of patients and mislabeling them as functional complainers.
C E Goodman; R K Lange; J Waxman; T E Weiss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  61     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  AIM; IM    
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MeSH Terms
Diphosphates / diagnostic use
HLA Antigens / analysis
Middle Aged
Sacroiliac Joint / radionuclide imaging
Sex Factors
Spondylitis, Ankylosing / diagnosis*,  immunology,  radionuclide imaging
Technetium / diagnostic use
Time Factors
Reg. No./Substance:
0/Diphosphates; 0/HLA Antigens; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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