Document Detail

Ankylosing spondylitis: a risk factor for myocardial infarction?
MedLine Citation:
PMID:  19403516     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To ascertain the prevalence of myocardial infarction (MI) in ankylosing spondylitis (AS) relative to that in the general population. METHODS: A questionnaire was sent to 593 patients with AS, aged between 50 and 75 years and registered at the Jan van Breemen Institute or VU University Medical Centre. A total of 383 (65%) patients with AS returned their questionnaire that covered the primary outcome, (non-fatal) MI. The prevalence of MI was calculated with data from the general population provided by Netherlands Information Network of General Practice databases as reference. RESULTS: The overall prevalence for MI was 4.4% in patients with AS versus 1.2% in the general population, resulting in an age- and gender-adjusted odds ratio of 3.1 (95% CI 1.9 to 5.1) for patients with AS. When non-responders (35%) were considered as non-MI the odds ratio decreased to 1.9 (95% CI 1.2 to 3.2). CONCLUSIONS: These observations indicate that the prevalence of MI is increased in patients with AS.
M J L Peters; I Visman; M M J Nielen; N Van Dillen; R A Verheij; I E van der Horst-Bruinsma; B A C Dijkmans; M T Nurmohamed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-28
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  69     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  579-81     Citation Subset:  IM    
Departments of Internal Medicine and Rheumatology, VU University Medical Centre, Amsterdam, Netherlands.
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MeSH Terms
Epidemiologic Methods
Middle Aged
Myocardial Infarction / epidemiology,  etiology*
Netherlands / epidemiology
Spondylitis, Ankylosing / complications*,  epidemiology

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