Document Detail

Anitschkow nuclear changes in postmortem pericardial scrapings.
MedLine Citation:
PMID:  11284306     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To document the presence of Anitschkow nuclear changes (ANC) in pericardial mesothelium at autopsy after the incidental finding of ANC in pericardial scrapings from a fatal case of overwhelming sepsis. STUDY DESIGN: Fourteen, nonconsecutive autopsy cases were studied. Using the edge of a scalpel, the visceral pericardium from the left ventricle was scraped, and the sample was smeared onto glass slides, fixed in 95% ethanol, Papanicolaou stained and evaluated for the presence of ANC. Histologic correlation was also performed. RESULTS: ANC were observed in pericardial mesothelial cells in 6 of 14 cases. Sepsis was the cause of death in three. Fatal cardiac arrhythmia, T-cell lymphoma and fulminant hepatic necrosis were found in the remaining cases. While readily seen in cytologic preparations, ANC were found focally in only one case examined histologically. CONCLUSION: Postmortem cytologic evaluation provides information relevant to the autopsy. In this study, ANC were very clearly seen in six pericardial scrapings. Clinical correlation supports the current theory that ANC represent a nonspecific reactive cell change.
C P Molina; V J Schnadig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  45     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Division of Cytopathology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0548, USA.
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MeSH Terms
Cell Nucleus / ultrastructure*
Epithelium / ultrastructure
Middle Aged
Pericardium / ultrastructure*

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