| Anisotropic mechanical properties of magnetically aligned fibrin gels measured by magnetic resonance elastography. | |
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MedLine Citation:
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PMID: 19656516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anisotropic mechanical properties of magnetically aligned fibrin gels were measured by magnetic resonance elastography (MRE) and by a standard mechanical test: unconfined compression. Soft anisotropic biomaterials are notoriously difficult to characterize, especially in vivo. MRE is well-suited for efficient, non-invasive, and non-destructive assessment of shear modulus. Direction-dependent differences in shear modulus were found to be statistically significant for gels polymerized at magnetic fields of 11.7 and 4.7 T compared to control gels. Mechanical anisotropy was greater in the gels polymerized at the higher magnetic field. These observations were consistent with results from unconfined compression tests. Analysis of confocal microscopy images of gels showed measurable alignment of fibrils in gels polymerized at 11.7 T. This study provides direct, quantitative measurements of the anisotropy in mechanical properties that accompanies fibril alignment in fibrin gels. |
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Authors:
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Ravi Namani; Matthew D Wood; Shelly E Sakiyama-Elbert; Philip V Bayly |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-05 |
Journal Detail:
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Title: Journal of biomechanics Volume: 42 ISSN: 1873-2380 ISO Abbreviation: J Biomech Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-07 Completed Date: 2009-11-23 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 2047-53 Citation Subset: IM |
Affiliation:
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Department of Mechanical, Aerospace & Structural Engineering, Washington University in St. Louis, MO 63130, USA. rnamani@seas.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anisotropy Compressive Strength Elasticity Imaging Techniques / methods* Fibrin / chemistry* Gels / chemistry* Hardness Image Interpretation, Computer-Assisted / methods* Magnetics Materials Testing / methods* Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS055951-01A1/NS/NINDS NIH HHS; R01 NS055951-02/NS/NINDS NIH HHS; R01 NS055951-03/NS/NINDS NIH HHS; R01 NS055951-04/NS/NINDS NIH HHS; R01NS055951/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gels; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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