Document Detail

Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo.
MedLine Citation:
PMID:  2217776     Owner:  NLM     Status:  MEDLINE    
Quantitative measurements of perfusion and molecular diffusion were made in human white matter in two orientations of the motion-sensitization gradient to document anisotropy of these parameters. Measurements were localized to a 10 X 10-mm tissue column oriented in an anterior-to-posterior direction in the left cerebral hemisphere just above the body of the left ventricle. This region was selected because of the relatively high directionality of white matter fibers. In this study of five healthy volunteers, strong diffusion anisotropy was observed in all cases. Twofold or greater anisotropy was commonly observed, with the higher diffusion value associated with motion sensitivity along the fiber directions. By combining data from both gradient orientations in all cases, diffusion values of solid tissue ranged from 0.38 X 10(-3) mm2/sec to 1.12 X 10(-3) mm2/sec, and measured perfusion fractions were in the range of 2%-5% (excluding areas highly contaminated by cerebrospinal fluid). Little or no perfusion-fraction anisotropy was observed; however, perfusion measurements were limited by noise. Data were collected without cardiac gating by using a technique that offers good immunity to bulk tissue motion artifacts.
T L Chenevert; J A Brunberg; J G Pipe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  177     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-11-21     Completed Date:  1990-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  AIM; IM    
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0030.
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MeSH Terms
Brain / physiology*
Cerebrospinal Fluid / physiology
Magnetic Resonance Imaging*
Nerve Fibers / physiology
Comment In:
Radiology. 1990 Nov;177(2):328-9   [PMID:  2217762 ]

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