Document Detail


Anisakis simplex sensitization-associated urticaria: short-lived immediate type or prolonged acute urticaria.
MedLine Citation:
PMID:  20628748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute urticaria is defined as evanescent wheals with a duration period of up to 6 weeks. Yet within acute urticaria, IgE-mediated urticaria lasts rarely more than 48 h, whereas longer duration periods are frequently unfruitful with respect to diagnostic work-up. We hypothesize the differences in immunologic features in immediate type urticaria versus prolonged acute urticaria within the model of Anisakis simplex (A. simplex) sensitization-associated urticaria. We included 57 patients with gastro-allergic Anisakiasis (GAA) and urticaria duration of less than 48 h and 17 patients with A. simplex sensitization-associated prolonged acute urticaria (PROL), defined as urticaria duration between 3 days and 6 weeks. As control group served 23 patients with A. simplex sensitization-associated chronic urticaria (CU+). We compared total IgE as well as specific IgE, IgG and IgG(4) against A. simplex. Median total IgE was higher in GAA than in PROL or CU+ [442 (interquartile range, IQR 198-995) vs. 117 (68-261) or 251 (94-382) kU/l, respectively]. Median-specific IgE was higher in GAA than in PROL or CU+ [62 (IQR 24.1-99) vs. 12.3 (6-30.9) or 14.2 (6.2-44.9) kU/l, respectively]. The differences were statistically significant at P < 0.001 for GAA against PROL and at P < 0.003 for GAA against CU+. Also, specific IgG and IgG(4) levels were higher in GAA than in PROL or CU+ at the same significance level. The levels of total IgE or specific immunoglobulin isotypes were not significantly different between PROL and CU+. In the model of A. simplex sensitization-associated urticaria, immediate-type urticaria in GAA is immunologically different from prolonged acute urticaria, which, in turn, shows features nearer to chronic urticaria than to gastro-allergic Anisakiasis. Thus, in an allergological evaluation of urticaria, we propose a possible benefit of a distinction of the duration period at 48 h, and not 6 weeks, when differentiating acute versus chronic urticaria.
Authors:
Alvaro Daschner; Consolación De Frutos; Ana Valls; Francisco Vega
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Publication Detail:
Type:  Journal Article     Date:  2010-07-14
Journal Detail:
Title:  Archives of dermatological research     Volume:  302     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  625-9     Citation Subset:  IM    
Affiliation:
Hospital Universitario de La Princesa, Madrid, Spain. alvarodaschner@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Anisakiasis / immunology*
Anisakis / immunology*
Antibodies, Helminth / blood*
Antigens, Helminth / immunology
Chronic Disease
Female
Humans
Immunoglobulin E / blood,  immunology
Immunoglobulin G / blood,  immunology
Male
Middle Aged
Skin Tests
Time Factors
Urticaria / immunology*,  parasitology*
Chemical
Reg. No./Substance:
0/Antibodies, Helminth; 0/Antigens, Helminth; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E

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