| Anisakis simplex sensitization-associated urticaria: short-lived immediate type or prolonged acute urticaria. | |
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MedLine Citation:
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PMID: 20628748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute urticaria is defined as evanescent wheals with a duration period of up to 6 weeks. Yet within acute urticaria, IgE-mediated urticaria lasts rarely more than 48 h, whereas longer duration periods are frequently unfruitful with respect to diagnostic work-up. We hypothesize the differences in immunologic features in immediate type urticaria versus prolonged acute urticaria within the model of Anisakis simplex (A. simplex) sensitization-associated urticaria. We included 57 patients with gastro-allergic Anisakiasis (GAA) and urticaria duration of less than 48 h and 17 patients with A. simplex sensitization-associated prolonged acute urticaria (PROL), defined as urticaria duration between 3 days and 6 weeks. As control group served 23 patients with A. simplex sensitization-associated chronic urticaria (CU+). We compared total IgE as well as specific IgE, IgG and IgG(4) against A. simplex. Median total IgE was higher in GAA than in PROL or CU+ [442 (interquartile range, IQR 198-995) vs. 117 (68-261) or 251 (94-382) kU/l, respectively]. Median-specific IgE was higher in GAA than in PROL or CU+ [62 (IQR 24.1-99) vs. 12.3 (6-30.9) or 14.2 (6.2-44.9) kU/l, respectively]. The differences were statistically significant at P < 0.001 for GAA against PROL and at P < 0.003 for GAA against CU+. Also, specific IgG and IgG(4) levels were higher in GAA than in PROL or CU+ at the same significance level. The levels of total IgE or specific immunoglobulin isotypes were not significantly different between PROL and CU+. In the model of A. simplex sensitization-associated urticaria, immediate-type urticaria in GAA is immunologically different from prolonged acute urticaria, which, in turn, shows features nearer to chronic urticaria than to gastro-allergic Anisakiasis. Thus, in an allergological evaluation of urticaria, we propose a possible benefit of a distinction of the duration period at 48 h, and not 6 weeks, when differentiating acute versus chronic urticaria. |
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Authors:
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Alvaro Daschner; Consolación De Frutos; Ana Valls; Francisco Vega |
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Publication Detail:
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Type: Journal Article Date: 2010-07-14 |
Journal Detail:
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Title: Archives of dermatological research Volume: 302 ISSN: 1432-069X ISO Abbreviation: Arch. Dermatol. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 625-9 Citation Subset: IM |
Affiliation:
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Hospital Universitario de La Princesa, Madrid, Spain. alvarodaschner@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Anisakiasis / immunology* Anisakis / immunology* Antibodies, Helminth / blood* Antigens, Helminth / immunology Chronic Disease Female Humans Immunoglobulin E / blood, immunology Immunoglobulin G / blood, immunology Male Middle Aged Skin Tests Time Factors Urticaria / immunology*, parasitology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Helminth; 0/Antigens, Helminth; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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