| Anionic polypeptide fraction in bile of patients with and without gallstones. | |
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MedLine Citation:
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PMID: 8491445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the demonstration of pronucleating and antinucleating proteins, the role of biliary proteins became of considerable research interest. Anionic polypeptide fraction is the third most abundant biliary protein; it is found in association with biliary lipids, has antinucleating properties for calcium and is found in gallstones. Its levels in various human biles have not been studied as of this writing. In this investigation the concentration of anionic polypeptide fraction in gallbladder bile was measured in 16 subjects without gallstones, 19 subjects with cholesterol stones and 15 subjects with pigment stones in Tel Aviv. Anionic polypeptide fraction concentrations in bile (mean +/- S.D.) were 0.76 +/- 0.09 gm/L in controls and 0.81 +/- 0.25 gm/L (which was not significant) in patients with cholesterol gallstones. They were significantly higher 1.03 +/- 0.23 (p < 0.05) in patients with pigment gallstones. The anionic polypeptide fraction/phospholipid ratio and the anionic polypeptide fraction/total lipid ratio were significantly higher in patients with pigment gallstones (p < 0.005 and 0.05, respectively). The anionic polypeptide fraction lipid ratios were insignificantly elevated in biles of patients with cholesterol stones compared with the ratios in biles of controls. Only the anionic polypeptide fraction/phospholipid ratio was significantly higher in biles of patients with pigment stones compared with those with cholesterol gallstones. The values were similar although higher in a small group of gallstone patients from Marseilles. The role of anionic polypeptide fraction in the pathogenesis of gallstones, particularly pigment gallstones, requires further study. |
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Authors:
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N Domingo; H Lafont; Z Halpern; Y Peled; J Grosclaude; T Gilat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 17 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-06-15 Completed Date: 1993-06-15 Revised Date: 2004-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 778-80 Citation Subset: IM |
Affiliation:
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Unité 130, INSERM, Marseilles, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apoproteins / analysis*, physiology Bile / chemistry* Biological Markers Calcium-Binding Proteins / analysis*, physiology Cholelithiasis / metabolism* Female Humans Lipids / analysis Male Middle Aged Phospholipids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Apoproteins; 0/Biological Markers; 0/Calcium-Binding Proteins; 0/Lipids; 0/Phospholipids; 0/anionic polypeptide fraction, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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