| Anion Transport in Liposomes Responds to Variations in the Anchor Chains and the Fourth Amino Acid of Heptapeptide Ion Channels. | |
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MedLine Citation:
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PMID: 19169373 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Seven heptapeptide derivatives have been prepared. The peptide structure is (Gly)(3)Xxx(Gly)(3) in which Xxx stands for a variable amino acid. The amino acid variations include azetidine carboxylic acid, pipecolic acid, meta-aminobenzoic acid, proline, and leucine. All seven compounds have a C-terminal benzyl group. In all cases, the heptapeptide's N-terminus was linked to diglycolic acid and a dialkylamine. In five cases, the N-terminal group was didecylamine and in two cases, N-ethyl-N-decyl. Chloride and carboxyfluorescein release from phospholipid vesicles was studied with the result that C(10)H(21)N(C(2)H(5)) COCH(2)OCH(2)CO-NH-(Gly)(3)Leu(Gly)(3)-OCH(2)Ph was the most active. Hill analysis showed that this compound involves pore formation by four monomer units rather than two, as previously found for other members of this family. |
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Authors:
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Riccardo Ferdani; Robert Pajewski; Natasha Djedovič; Jolanta Pajewska; Paul H Schlesinger; George W Gokel |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: New journal of chemistry = Nouveau journal de chimie Volume: 29 ISSN: 1144-0546 ISO Abbreviation: New J Chem Publication Date: 2005 |
Date Detail:
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Created Date: 2009-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709755 Medline TA: New J Chem Country: - |
Other Details:
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Languages: ENG Pagination: 673-280 Citation Subset: - |
Affiliation:
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Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8103, St. Louis, MO 63110 USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 GM063190-04S1//NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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