Document Detail


Anion Transport in Liposomes Responds to Variations in the Anchor Chains and the Fourth Amino Acid of Heptapeptide Ion Channels.
MedLine Citation:
PMID:  19169373     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Seven heptapeptide derivatives have been prepared. The peptide structure is (Gly)(3)Xxx(Gly)(3) in which Xxx stands for a variable amino acid. The amino acid variations include azetidine carboxylic acid, pipecolic acid, meta-aminobenzoic acid, proline, and leucine. All seven compounds have a C-terminal benzyl group. In all cases, the heptapeptide's N-terminus was linked to diglycolic acid and a dialkylamine. In five cases, the N-terminal group was didecylamine and in two cases, N-ethyl-N-decyl. Chloride and carboxyfluorescein release from phospholipid vesicles was studied with the result that C(10)H(21)N(C(2)H(5)) COCH(2)OCH(2)CO-NH-(Gly)(3)Leu(Gly)(3)-OCH(2)Ph was the most active. Hill analysis showed that this compound involves pore formation by four monomer units rather than two, as previously found for other members of this family.
Authors:
Riccardo Ferdani; Robert Pajewski; Natasha Djedovič; Jolanta Pajewska; Paul H Schlesinger; George W Gokel
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  New journal of chemistry = Nouveau journal de chimie     Volume:  29     ISSN:  1144-0546     ISO Abbreviation:  New J Chem     Publication Date:  2005  
Date Detail:
Created Date:  2009-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709755     Medline TA:  New J Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  673-280     Citation Subset:  -    
Affiliation:
Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8103, St. Louis, MO 63110 USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 GM063190-04S1//NIGMS NIH HHS

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