Document Detail

Animal spongiform encephalopathies--an update. Part 1. Scrapie and lesser known animal spongiform encephalopathies.
MedLine Citation:
PMID:  7871704     Owner:  NLM     Status:  MEDLINE    
The present article (part I) reviews recent developments in animal spongiform encephalopathies (SEs), with the exception of bovine spongiform encephalopathy (BSE), which is dealt with in part II. The article focuses on scrapie and describes epidemiological aspects and the prospects for a preclinical diagnosis. Up to now, confirmatory diagnosis of scrapie depended on histological examination of the brain, collected during post-mortem examination from sheep with clinical signs of the disease. An altered protein, PrPSc, can be detected in the brain of diseased animals. The demonstration of the same protein in the spleen and in peripheral lymph nodes of infected animals seems to offer interesting possibilities of arriving at a method for a preclinical diagnosis, and thus a diagnosis in the live animal. Progress has also been made in our understanding of the relationship between the genetic constitution and susceptibility of the host. Susceptibility is expressed as the survival time of sheep inoculated with scrapie. This was thought to be determined by a single genetic locus designated the Sip gene (scrapie incubation period gene). Putative markers for the two alleles of the Sip gene, sA and pA, have been discovered, consisting of restriction fragment length polymorphisms (RFLPs). In field tests, however, the link between these markers and the length of incubation time was far from consistent. These RFLPs were found to be situated outside the prion-protein-coding region of the ovine gene. In later studies, RFLPs were detected inside this region. These markers appear to be more informative, i.e. they correspond with a difference in the length of the scrapie incubation period.(ABSTRACT TRUNCATED AT 250 WORDS)
B E Schreuder
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Veterinary quarterly     Volume:  16     ISSN:  0165-2176     ISO Abbreviation:  Vet Q     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-27     Completed Date:  1995-03-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7909485     Medline TA:  Vet Q     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  174-81     Citation Subset:  IM    
DLO-Central Veterinary Institute, Lelystad, The Netherlands.
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MeSH Terms
Animals, Wild*
Animals, Zoo*
Cat Diseases / diagnosis,  epidemiology,  genetics,  transmission
Prions / genetics
Scrapie / diagnosis*,  epidemiology,  genetics,  transmission
Reg. No./Substance:

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