Document Detail

Animal responses to extreme conditions: a lesson to biomedical research.
MedLine Citation:
PMID:  17242469     Owner:  NLM     Status:  MEDLINE    
Various animals must cope with some specific extreme environmental conditions and, as a consequence, they developed extremely efficacious adaptive defence responses. The mechanisms of the specific defences are more clearly visible in some species than in humans. Therefore, animal models of the human defence mechanisms should be selected accordingly. The appropriate, well responding models may be regarded as "biological amplifiers". This review is focussed on examples of effective defence against: (i) parturitional asphyxia, which extends fertility of mammals; (ii) diving asphyxia, which extends access of food in aquatic birds and mammals; (iii) endotoxemia, which provides survival of the fittest in mammals showing top fertility; (iv) deep hypothermia, which enables hibernating mammals to arouse. Each of the defences needs close co-operation of the cardiovascular, respiratory and temperature regulatory systems. Underlined problems regarding a choice of appropriate experimental animal models should stimulate renaissance of comparative physiology.
M Caputa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  57 Suppl 8     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-12-06     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  7-15     Citation Subset:  IM    
Department of Animal Physiology, Institute of General and Molecular Biology, N. Copernicus University, Toruń, Poland.
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MeSH Terms
Adaptation, Physiological*
Animals, Laboratory
Asphyxia Neonatorum
Defense Mechanisms*
Infant, Newborn
Models, Animal*

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