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Animal models to detect allergenicity to foods and genetically modified products: workshop summary.
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MedLine Citation:
PMID:  12573909     Owner:  NLM     Status:  MEDLINE    
Respiratory allergy and allergy to foods continue to be important health issues. There is evidence to indicate that the incidence of food allergy around the world is on the rise. Current estimates indicate that approximately 5% of young children and 1-2% of adults suffer from true food allergy (Kagan 2003). Although a large number of in vivo and in vitro tests exist for the clinical diagnosis of allergy in humans, we lack validated animal models of allergenicity. This deficiency creates serious problems for regulatory agencies and industries that must define the potential allergenicity of foods before marketing. The emergence of several biotechnologically derived foods and industrial proteins, as well as their potential to sensitize genetically predisposed populations to develop allergy, has prompted health officials and regulatory agencies around the world to seek approaches and methodologies to screen novel proteins for allergenicity.
Helen Tryphonas; George Arvanitakis; Elizabeth Vavasour; Genevieve Bondy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  111     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-05-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-2     Citation Subset:  IM    
Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.
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MeSH Terms
Animals, Genetically Modified / immunology*
Disease Models, Animal*
Food, Genetically Modified / adverse effects*
Hypersensitivity / immunology*,  veterinary
Mice, Inbred BALB C
Plants, Genetically Modified / immunology*
Risk Assessment
T-Lymphocytes / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 2 Year: 2003
Volume: 111 Issue: 2
First Page: 221 Last Page: 222
ID: 1241354
PubMed Id: 12573909

Animal models to detect allergenicity to foods and genetically modified products: workshop summary.
Helen Tryphonas
George Arvanitakis
Elizabeth Vavasour
Genevieve Bondy
Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.

Article Categories:
  • Research Article

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