Document Detail


Animal models for the study of fetal tissue repair.
MedLine Citation:
PMID:  1908924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent experimental and clinical evidence suggests that the fetus responds to injury in a fashion fundamentally different from that of the adult. Acute inflammation is almost always absent, hyaluronic acid is a prominent component of the wound matrix, and collagen is deposited in a scarless manner. Using a variety of animal models and techniques, numerous investigators have begun to analyze the constituents of the fetal wound healing process in an attempt to understand the control mechanisms that endow the fetus with unique healing abilities. Since scarring and fibrosis dominate some diseases in almost every medical specialty, the ultimate clinical aim is to delineate the biological principles of fetal wound healing and then apply them to modulate adult wound healing problems.
Authors:
N S Adzick; M T Longaker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of surgical research     Volume:  51     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  216-22     Citation Subset:  IM    
Affiliation:
Fetal Treatment Program, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Disease Models, Animal
Fetus / physiology*
Guinea Pigs
Haplorhini
Mice
Opossums
Rabbits
Rats
Sheep
Wound Healing*
Grant Support
ID/Acronym/Agency:
HD25502/HD/NICHD NIH HHS; HL39875/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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