| Animal models for small for gestational age and fetal programming of adult disease. | |
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MedLine Citation:
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PMID: 17351325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal growth retardation is a fetal adaptation in response to inadequate supply of oxygen and/or nutrients. Animal models of intrauterine growth retardation are an invaluable tool to question the genetic, molecular and cellular events that determine fetal growth and development. Rodent and non-litter bearing animals are mammalian system with similar embryology,anatomy and physiology to humans. Utilization of these systems has led to a greater understanding of the pathophysiology and consequences of intrauterine growth retardation. These observations are comparable to that observed in humans born small for gestational age, and are of interest because of the known association between poor fetal growth and development of adult disease. All the experimental manipulations described here have altered a number of metabolic and physiological variables, but the pattern of alterations seems to vary with the procedure and species employed. This review describes animal models for intrauterine growth retardation and assesses their potentials and limitations at aiming to improve strategies for the prevention of adult disease. |
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Authors:
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Patricia M Vuguin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2007-03-09 |
Journal Detail:
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Title: Hormone research Volume: 68 ISSN: 1423-0046 ISO Abbreviation: Horm. Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-10 Completed Date: 2007-09-04 Revised Date: 2010-03-18 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 113-23 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA. vuguin@aecom.yu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications Caloric Restriction Cardiovascular Diseases / etiology Disease Models, Animal* Female Fetal Growth Retardation / physiopathology* Glucocorticoids / toxicity Guinea Pigs Humans Infant, Newborn Infant, Small for Gestational Age / physiology* Kidney Diseases / etiology Ligation Mice Pregnancy Pregnancy in Diabetics / physiopathology Protein Deficiency / complications Rats Sheep Stress, Physiological / complications Swine Uterus / blood supply |
| Grant Support | |
ID/Acronym/Agency:
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K08 HD042172/HD/NICHD NIH HHS; K08 HD042172-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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