Document Detail


Animal models for HIV/AIDS research.
MedLine Citation:
PMID:  23154262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years of intensive investigation, we still lack the basic scientific knowledge necessary to produce a safe and effective vaccine against HIV-1. Animal models offer obvious advantages in the study of HIV/AIDS, allowing for a more invasive investigation of the disease and for preclinical testing of drugs and vaccines. Advances in humanized mouse models, non-human primate immunogenetics and recombinant challenge viruses have greatly increased the number and sophistication of available mouse and simian models. Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection.
Authors:
Theodora Hatziioannou; David T Evans
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  10     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-02-07     Revised Date:  2013-11-01    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  852-67     Citation Subset:  IM    
Affiliation:
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA. thatziio@adarc.org
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / immunology,  pharmacology*
Acquired Immunodeficiency Syndrome / immunology*,  prevention & control*
Animals
Anti-HIV Agents / pharmacology*
Disease Models, Animal*
HIV / immunology*
HIV Infections / immunology*,  prevention & control*
Humans
Grant Support
ID/Acronym/Agency:
AI078788/AI/NIAID NIH HHS; AI087498/AI/NIAID NIH HHS; AI093255/AI/NIAID NIH HHS; AI095098/AI/NIAID NIH HHS; AI098485/AI/NIAID NIH HHS; P51 RR000168/RR/NCRR NIH HHS; R01 AI095098/AI/NIAID NIH HHS; R01 AI098485/AI/NIAID NIH HHS; R21 AI087498/AI/NIAID NIH HHS; RR000168/OD011103/OD/NIH HHS
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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