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Animal models for prenatal gene therapy: the sheep model.
MedLine Citation:
PMID:  22648775     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Large animal experiments are vital in the field of prenatal gene therapy, to allow translation from small animals into man. Sheep provide many advantages for such experiments. They have been widely used in research into fetal physiology and pregnancy and the sheep fetus is a similar size to that in the human. Sheep are tolerant to in utero manipulations such as fetoscopy or even hysterotomy, and they are cheaper and easier to maintain than non-human primates. In this chapter, we describe the animal husbandry involved in generating time-mated sheep pregnancies, the large number of injection routes in the fetus that can be achieved using ultrasound or fetoscopic-guided injection, and laparotomy when these more minimally invasive routes of injection are not feasible.
Authors:
Khalil N Abi-Nader; Michael Boyd; Alan W Flake; Vedanta Mehta; Donald Peebles; Anna L David
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  891     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-48     Citation Subset:  IM    
Affiliation:
Prenatal Cell and Gene Therapy Group, EGA Institute for Women's Health, University College London, London, UK.
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