Document Detail

Animal models of preeclampsia.
MedLine Citation:
PMID:  15529295     Owner:  NLM     Status:  MEDLINE    
There have been many attempts to produce animal models that mimic the hypertensive disorders of pregnancy, especially preeclampsia, but most are incomplete when compared to the full spectrum of the human disease. This review assesses a number of these models, organized according to the investigators attempt to focus on a specific pathogenic mechanism believed to play a role in the human disease. These mechanisms include uterine ischemia, impairments in the nitric oxide system, insulin resistance, overactivity of the autonomic nervous and/or renin-angiotensin systems, activation of a systemic inflammatory response, and most recently, activation of circulating proteins that interfere with angiogenesis. In addition a model of renal disease that mimics superimposed preeclampsia is discussed. Defining these animal models should help in our quest to understand the cause, as well as to test preventative and therapeutic strategies in the management of these hypertensive disorders of pregnancy.
Eduardo Podjarny; Gyorgy Losonczy; Chris Baylis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  24     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-05     Completed Date:  2005-09-13     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  596-606     Citation Subset:  IM    
Department of Nephrology and Hypertension, Meir Hospital, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
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MeSH Terms
Disease Models, Animal*
Doxorubicin / administration & dosage
Kidney Diseases / chemically induced
Placenta / ultrasonography
Uterus / blood supply
Grant Support
R01 HL031933-12/HL/NHLBI NIH HHS
Reg. No./Substance:

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