Document Detail

Animal models of neonatal stroke and response to erythropoietin and cardiotrophin-1.
MedLine Citation:
PMID:  18036763     Owner:  NLM     Status:  MEDLINE    
Neonatal stroke is increasingly recognized in preterm and term infants, and the rate of arterial ischemic infarction occurring around the time of birth is as high as the annual incidence of large-vessel ischemic stroke in adults. Thus, neonatal stroke is a major contributor to perinatal morbidity and mortality, and a considerable number of these children will develop long-term neurodevelopmental disabilities. Our ability to investigate this situation has been limited by the technical challenges in developing suitable animal models. Our objective is to describe recent evidence in relation to animal models of neonatal stroke. In addition, we review and report potential neuroprotective strategies specific to neonatal stroke, with a focus on erythropoietin and cardiotrophin-1 because of their potential role in protection as well as repair.
Augusto Sola; Hui Peng; Marta Rogido; Tong-Chun Wen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-09-12
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  26     ISSN:  0736-5748     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-35     Citation Subset:  IM    
Division of Neonatology, MANA and Atlantic Neonatal Research Institute, Morristown, NJ 07960, USA.
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MeSH Terms
Animals, Newborn
Cytokines / therapeutic use*
Disease Models, Animal
Dose-Response Relationship, Drug
Erythropoietin / therapeutic use*
Nerve Tissue Proteins / metabolism
Neuroprotective Agents / therapeutic use*
Risk Factors
Stroke / drug therapy*,  epidemiology,  metabolism,  physiopathology
Time Factors
Reg. No./Substance:
0/Cytokines; 0/Nerve Tissue Proteins; 0/Neuroprotective Agents; 0/cardiotrophin 1; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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