Document Detail


Animal models of intestinal inflammation: ineffective communication between coalition members.
MedLine Citation:
PMID:  16028027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The microbiota, epithelial cells, and mucosal immune cells in the intestine comprise an important gastrointestinal coalition. The intestinal microbiota can exert both beneficial as well as deleterious effects on their animal hosts. They interact with the innate defenses provided by epithelial cells through microbial recognition receptors. This communication, under normal conditions, results in a state of controlled inflammation. This article will focus on several animal models of intestinal inflammation, in which spontaneous or induced mutations or other genetic manipulations result in severe alterations in one of the members of the gastrointestinal coalition. These animal models of colitis have shown that alterations in communication between members of this coalition ultimately lead to gastrointestinal disease.
Authors:
Robin G Lorenz; Vance J McCracken; Charles O Elson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2005-07-19
Journal Detail:
Title:  Springer seminars in immunopathology     Volume:  27     ISSN:  0344-4325     ISO Abbreviation:  Springer Semin. Immunopathol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2008-07-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910384     Medline TA:  Springer Semin Immunopathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  233-47     Citation Subset:  IM    
Affiliation:
Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / immunology,  pathogenicity
Colitis / immunology*,  microbiology*
Cytokines / immunology,  metabolism
Disease Models, Animal
Epithelial Cells / immunology,  microbiology
Gastroenteritis / immunology*,  microbiology*
Immunity, Active
Immunity, Innate
Intestinal Mucosa / immunology*,  metabolism
Intestines / immunology*
T-Lymphocyte Subsets / immunology,  metabolism
Grant Support
ID/Acronym/Agency:
DK064400/DK/NIDDK NIH HHS; DK44240/DK/NIDDK NIH HHS; DK59911/DK/NIDDK NIH HHS; DK60132/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines

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