Document Detail


Animal models in food allergy: assessment of allergenicity and preventive activity of infant formulas.
MedLine Citation:
PMID:  12676478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food allergies occur in about 5-10% of the overall infant and small-child population. Cow's milk protein allergy (CMPA) is the most common in young infants, with a 2-4% incidence. When breastfeeding is not possible, hypoallergenic (HA) cow's milk based formulas are usually given during the first months of life for prevention of CMPA. Depending on primary (sensitization) or secondary (triggering) prevention, the requested quality of HA formulas may be different. Besides in vitro methods, in vivo and ex vivo animal models are helpful in assessing residual allergenicity and the preventive effect of HA formulas. The sensitizing capacity of a formula can be examined by either the parenteral rat (IgE), the guinea pig (IgG1a mediated) or the oral mouse (IgE) models. The triggering IgE mediated allergenicity is tested by a parenteral rat model with oral gavage for intestinal mast cell protease (RMCPII) release. These animal models are also used for testing the oral tolerance inducing capacities of formulas. Together with cellular in vitro assays, animal models are very helpful in predicting allergenicity and the tolerogenic potential of HA infant formulas.
Authors:
Rodolphe Fritsché
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology letters     Volume:  140-141     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-04     Completed Date:  2003-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  303-9     Citation Subset:  IM    
Affiliation:
Nestlé Research Center, Vers-chez-les-Blanc, P.O. Box 44, CH-1000 26, Lausanne, Switzerland. rodolphe.fritische@rdls.nestle.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Chymases
Food Hypersensitivity* / diagnosis,  metabolism,  prevention & control
Humans
Hypersensitivity, Immediate / epidemiology,  etiology*,  prevention & control
Infant
Infant Food / adverse effects*
Models, Animal*
Serine Endopeptidases / secretion*
Chemical
Reg. No./Substance:
EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.39/Chymases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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