| Animal models of hypertension. | |
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MedLine Citation:
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PMID: 18287667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension. |
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Authors:
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Brett M Mitchell; Thomas Wallerath; Ulrich Förstermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Methods in molecular medicine Volume: 139 ISSN: 1543-1894 ISO Abbreviation: Methods Mol. Med. Publication Date: 2007 |
Date Detail:
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Created Date: 2008-02-21 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101123138 Medline TA: Methods Mol Med Country: United States |
Other Details:
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Languages: eng Pagination: 105-11 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine Texas A&M Health Science, Center-College of Medicine Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dexamethasone / administration & dosage, pharmacology Disease Models, Animal* Drinking GTP Cyclohydrolase / administration & dosage, pharmacology Humans Hypertension / chemically induced, physiopathology* Nitric Oxide Synthase / administration & dosage, pharmacology Rats Water / chemistry |
| Chemical | |
Reg. No./Substance:
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50-02-2/Dexamethasone; 7732-18-5/Water; EC 1.14.13.39/Nitric Oxide Synthase; EC 3.5.4.16/GTP Cyclohydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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