Document Detail

Animal models of hypertension.
MedLine Citation:
PMID:  18287667     Owner:  NLM     Status:  MEDLINE    
Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.
Brett M Mitchell; Thomas Wallerath; Ulrich Förstermann
Related Documents :
12605267 - Influence of arterial hypertension and diet-induced atherosclerosis on macular drusen.
24445737 - Uva irradiation of human skin vasodilates arterial vasculature and lowers blood pressur...
17299567 - The prevalence of diastolic dysfunction in adult hypertensive nigerians.
20160537 - Hypertensive crisis.
17478167 - The president and the pheochromocytoma.
16486277 - Macroscopic capillarity and hysteresis for flow in porous media.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  139     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2008-02-21     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
Department of Internal Medicine Texas A&M Health Science, Center-College of Medicine Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dexamethasone / administration & dosage,  pharmacology
Disease Models, Animal*
GTP Cyclohydrolase / administration & dosage,  pharmacology
Hypertension / chemically induced,  physiopathology*
Nitric Oxide Synthase / administration & dosage,  pharmacology
Water / chemistry
Reg. No./Substance:
50-02-2/Dexamethasone; 7732-18-5/Water; EC Oxide Synthase; EC Cyclohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical animal model of ventricular hypertrophy.
Next Document:  Rat models of cardiac insulin resistance.