Document Detail


Animal models of hypertension.
MedLine Citation:
PMID:  18287667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.
Authors:
Brett M Mitchell; Thomas Wallerath; Ulrich Förstermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  139     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2008-02-21     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine Texas A&M Health Science, Center-College of Medicine Texas, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dexamethasone / administration & dosage,  pharmacology
Disease Models, Animal*
Drinking
GTP Cyclohydrolase / administration & dosage,  pharmacology
Humans
Hypertension / chemically induced,  physiopathology*
Nitric Oxide Synthase / administration & dosage,  pharmacology
Rats
Water / chemistry
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone; 7732-18-5/Water; EC 1.14.13.39/Nitric Oxide Synthase; EC 3.5.4.16/GTP Cyclohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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