Document Detail

Animal models of food allergy.
MedLine Citation:
PMID:  14752339     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The focus of this review will be on recent animal models of food allergy. Animal models are being used to investigate underlying mechanisms of IgE-mediated disease and for prophylactic/intervention therapies to treat allergic disease. RECENT FINDINGS: Considerable advances have been made in the dosage and use of sensitization routes with and without adjuvant and determinations of the pathophysiology of food allergy in murine, dog and swine food allergy models. Continued research on the neuroendocrine and novel immunoregulatory peptides is also providing new insight into inflammatory regulation and immunity. With the advent of genetically modified food crops, animal models are becoming a central theme for prediction/assessment of allergenicity for novel proteins based upon known food allergens. Therapeutic strategies involving cytokine and allergen, DNA immunizations and the use of probiotics are receiving new interest. SUMMARY: Although murine models still predominate the literature with respect to animal models of food allergy, the atopic dog and neonatal swine model are contributing knowledge with respect to symptoms more closely related to human allergic responses. Continuing investigations into the mechanisms of IgE-mediated food allergy and therapeutic strategies are providing new insights into prevention and intervention therapies for food allergy.
Ricki M Helm; A Wesley Burks
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  2     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
ACHRI/UAMS, Department of Pediatrics, Little Rock, Arkansas 72202, USA.
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MeSH Terms
Allergens / pharmacology
Desensitization, Immunologic / methods*
Disease Models, Animal
Food Hypersensitivity / immunology*,  therapy*
Immunotherapy / methods
Sensitivity and Specificity
Skin Tests
Species Specificity
Reg. No./Substance:

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