Document Detail

Animal models of coronary spasm and the pathophysiological events in regional vascular hypercontraction.
MedLine Citation:
PMID:  3968859     Owner:  NLM     Status:  MEDLINE    
An animal model of coronary spasm was designed 1) to reproduce coronary spasm similar to that seen in patients with variant angina, 2) to determine whether hypercontraction of the vascular smooth muscle occurs at the site of the spasm, 3) to document the relationship between functional and structural changes of the vascular wall and 4) to characterize the pathophysiological features of coronary spasm. After balloon de-endothelialization and feeding of a high cholesterol diet in mongrel dogs and Göttingen miniature pigs, there was evidence of vascular hypercontraction associated with arteriosclerotic changes. Coronary spasm of more than 75% narrowing of the artery was provoked with ischemic signs in miniature swine. These events could be repeatedly provoked by an intracoronary injection of histamine following pretreatment with cimetidine. The site of hypercontraction corresponded well with the site of the de-endothelialization, an area where the basal vascular tone was increased and was related to histamine activity. Thus, the present animal model will shed light on mechanism involved in vasoactive angina pectoris and aid in clarifying the pathophysiology of vascular smooth muscle.
H Tomoike
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  49     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-19     Completed Date:  1985-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
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MeSH Terms
Cimetidine / pharmacology
Coronary Angiography
Coronary Circulation
Coronary Disease / pathology,  physiopathology
Coronary Vasospasm / etiology,  pathology,  physiopathology*
Coronary Vessels / pathology
Ergonovine / pharmacology
Histamine / pharmacology
Muscle, Smooth, Vascular / physiopathology*
Serotonin / pharmacology
Swine, Miniature
Reg. No./Substance:
50-67-9/Serotonin; 51-45-6/Histamine; 51481-61-9/Cimetidine; 60-79-7/Ergonovine

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