Document Detail

Animal model of spinal cord infarction induced by cholesterol embolization.
MedLine Citation:
PMID:  7825653     Owner:  NLM     Status:  MEDLINE    
Though several animal models of ischemic brain infarction have been developed, no animal model of purely ischemic spinal cord infarction exists. In humans, such paralysis often occurs as a complication of aortic surgery. While working on an animal model of cholesterol embolic renal disease, the authors produced an animal model of ischemic spinal paralysis by direct intraaortic injection of cholesterol suspension. With histologic examination of spinal cords of the paralyzed rats, prominent cholesterol crystals were found obliterating the lumen of the anterior and/or posterior spinal arteries. Spinal cord infarction was seen most prominently in the lateral columns and anterior horns, though other areas also were affected. Permanent paraplegia developed in most rats, but transient paralysis developed in a few, followed by partial or full recovery. This model of spinal infarction in nonanesthetized rats can be used to study the pathophysiology and therapy of spinal infarction.
M G Saklayen; D L Goldstein; Y S Park; T Mathews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  309     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-13     Completed Date:  1995-02-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  AIM; IM    
Department of Medicine, V.A. Medical Center, Dayton, Ohio.
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MeSH Terms
Arteries / chemistry,  pathology
Cholesterol* / analysis
Disease Models, Animal
Infarction / chemically induced,  pathology*
Spinal Cord / blood supply*,  pathology
Reg. No./Substance:

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