Document Detail


Animal model for percutaneous creation of traumatic thoracic aortic transection.
MedLine Citation:
PMID:  18192474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study was conducted to create an animal model for thoracic aortic transection that is suitable for thoracic endograft research. MATERIALS AND METHODS: Percutaneous aortic transection creation was attempted in 12 sheep. A custom collapsible circumferential cutting device was inserted into the proximal descending thoracic aorta via a femoral approach with an 11-F delivery catheter. The device was deployed 2 cm distal to the left subclavian artery origin and rotated 20 times to create aortic transection. Aortic diameters, mean aortic pressures, and heart rates were tested for degrees of difference between measurements before and after the creation of transection. On necropsy, the extent of aortic damage was classified as none, nontransmural, or transmural, and aortic transection was classified as none, partial, or circumferential. RESULTS: On angiography, creation of transmural thoracic aortic transection was successful in 91.7% (11/12) of animals. Aortic transection was circumferential in 54.4% (6/11) of animals and partial in 45.6% (5/11) of animals. Mean aortic diameter was 19.6 +/- 3.4 mm (range 12-24 mm) pre-transection and 25.8 +/- 4.5 mm (range 17.8-33 mm) post-transection (P = .0003). Pre-transection, mean aortic pressure was 79 +/- 13.8 mmHg, and 64.6 +/- 15.8 mmHg 15 min post-transection (P = .041). Pre-transection, mean heart rate was 94.5 +/- 17.2 beats per minute (bpm), and 105.8 +/- 17.2 bpm 15 min post-transection (P = .0057). CONCLUSIONS: Thoracic aortic transection was successfully created percutaneously in most animals. The animals remained in hemodynamically stable condition for as long as 240 minutes after the creation of aortic injury. This percutaneous animal model is straightforward and may be of potential value for future thoracic endograft research.
Authors:
Hanno Hoppe; Won-Kyu Park; Luiz O Correa; Wie Lu; Long Liu; Hans A Timmermanns; Dusan Pavcnik; Barry T Uchida; Howard K Song; Josef Rösch; John A Kaufman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  19     ISSN:  1051-0443     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Affiliation:
Dotter Interventional Institute, Oregon Health & Science University, Portland, OR, USA. hanno.hoppe@web.de
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MeSH Terms
Descriptor/Qualifier:
Aneurysm, Dissecting / pathology*,  physiopathology,  radiography
Aneurysm, False / pathology*,  physiopathology,  radiography
Angioplasty* / instrumentation
Animals
Aorta, Thoracic / injuries,  pathology,  physiopathology,  radiography,  surgery*
Aortic Aneurysm, Thoracic / pathology*,  physiopathology,  radiography
Aortography
Blood Pressure
Disease Models, Animal*
Female
Heart Rate
Prosthesis Design
Sheep
Vena Cava Filters
Wounds and Injuries / pathology*,  physiopathology,  radiography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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