Document Detail


Animal model of anxiety: effect of nicergoline in the genetically hypertensive rats of Koletsky type and in the rats of Wistar strain.
MedLine Citation:
PMID:  2799259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The experiments were performed in the adult normotensive rats of Wistar strain and in the genetically hypertensive rats of Koletsky type; both sexes were used. The behavior in control and in Nicergoline treated rats was traced in holeboard and in the elevated plus-maze. In the control animals, when compared to the normotensive rats of Wistar strain, the genetically hypertensive rats of both sexes show elevated aversion towards open space and hight in the elevated plus-maze, reduced time spent head dipping in holeboard. The genetically hypertensive rats show maximal neophobia in the first minute of the first session in the holeboard. Nicergoline at the dose of 8 mg/kg b. w. reduced the aversion towards the open space and hight in elevated plus-maze only in the genetically hypertensive rats of both sexes. Moreover, Nicergoline in the genetically hypertensive males alleviates neophobic hypoactivity, increase head-dipping in the first session, increases head-dipping in the genetically hypertensive females in the second session. Nicergoline also decreases total time of locomotor-exploratory activity on holeboard in the males of both strains in the first session, in the second session the same effect of Nicergoline was found in all groups of rats except the genetically hypertensive females.
Authors:
V Golda; R Petr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sborník vědeckých prací Lékařské fakulty Karlovy university v Hradci Králové     Volume:  32     ISSN:  0049-5514     ISO Abbreviation:  Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-08     Completed Date:  1989-11-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0414147     Medline TA:  Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  109-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / drug therapy*
Behavior, Animal / drug effects
Ergolines / therapeutic use*
Female
Male
Nicergoline / therapeutic use*
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Ergolines; 27848-84-6/Nicergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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