Document Detail


Animal models of osteoarthritis: challenges of model selection and analysis.
MedLine Citation:
PMID:  23329424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of individuals worldwide. New treatment approaches require an understanding of the pathophysiology of OA and its biomechanical, inflammatory, genetic, and environmental risk factors. The purpose of animal models of OA is to reproduce the pattern and progression of degenerative damage in a controlled fashion, so that opportunities to monitor and modulate symptoms and disease progression can be identified and new therapies developed. This review discusses the features, strengths, and weaknesses of the common animal models of OA; considerations to be taken when choosing a method for experimental induction of joint degeneration; and the challenges of measuring of OA progression and symptoms in these models.
Authors:
Erin Teeple; Gregory D Jay; Khaled A Elsaid; Braden C Fleming
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-18
Journal Detail:
Title:  The AAPS journal     Volume:  15     ISSN:  1550-7416     ISO Abbreviation:  AAPS J     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-10-22     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  101223209     Medline TA:  AAPS J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  438-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology
Arthralgia / diagnosis,  etiology,  physiopathology
Biological Markers / metabolism
Disease Models, Animal*
Disease Progression
Gait
Joints* / drug effects,  metabolism,  pathology,  physiopathology
Osteoarthritis* / diagnosis,  drug therapy,  etiology,  metabolism,  physiopathology
Pain Measurement
Predictive Value of Tests
Prognosis
Reproducibility of Results
Severity of Illness Index
Species Specificity
Time Factors
Grant Support
ID/Acronym/Agency:
2P20 GM104937/GM/NIGMS NIH HHS; P20 RR024484/RR/NCRR NIH HHS; R01 AR056834/AR/NIAMS NIH HHS; R01-AR056834/AR/NIAMS NIH HHS; R41 AR057276/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biological Markers
Comments/Corrections

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