Document Detail


Angiotensins in Alzheimer's disease - friend or foe?
MedLine Citation:
PMID:  19796831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The renin-angiotensin system (RAS) is an important regulator of blood pressure. Observational and experimental studies suggest that alterations in blood pressure and components of the brain RAS contribute to the development and progression of Alzheimer's disease (AD), resulting in changes that can lead or contribute to cognitive decline. The complexity of the RAS and diversity of its interactions with neurological processes have recently become apparent but large gaps in our understanding still remain. Modulation of activity of components of the brain RAS offers substantial opportunities for the treatment and prevention of dementia, including AD. This paper reviews molecular, genetic, experimental and clinical data as well as the therapeutic opportunities that relate to the involvement of the RAS in AD.
Authors:
Patrick G Kehoe; Scott Miners; Seth Love
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-30
Journal Detail:
Title:  Trends in neurosciences     Volume:  32     ISSN:  1878-108X     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-28     Citation Subset:  IM    
Affiliation:
Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK. Patrick.Kehoe@bristol.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy,  etiology,  genetics,  metabolism*
Angiotensin II Type 1 Receptor Blockers / pharmacology,  therapeutic use
Angiotensin-Converting Enzyme Inhibitors / pharmacology,  therapeutic use
Angiotensins / drug effects,  metabolism*
Animals
Brain / metabolism,  physiopathology
Cognition / drug effects
Disease Models, Animal
Humans
Models, Biological
Renin-Angiotensin System / drug effects,  genetics,  physiology*
Chemical
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Angiotensins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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