| Angiotensins in Alzheimer's disease - friend or foe? | |
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MedLine Citation:
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PMID: 19796831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin system (RAS) is an important regulator of blood pressure. Observational and experimental studies suggest that alterations in blood pressure and components of the brain RAS contribute to the development and progression of Alzheimer's disease (AD), resulting in changes that can lead or contribute to cognitive decline. The complexity of the RAS and diversity of its interactions with neurological processes have recently become apparent but large gaps in our understanding still remain. Modulation of activity of components of the brain RAS offers substantial opportunities for the treatment and prevention of dementia, including AD. This paper reviews molecular, genetic, experimental and clinical data as well as the therapeutic opportunities that relate to the involvement of the RAS in AD. |
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Authors:
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Patrick G Kehoe; Scott Miners; Seth Love |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-09-30 |
Journal Detail:
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Title: Trends in neurosciences Volume: 32 ISSN: 1878-108X ISO Abbreviation: Trends Neurosci. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808616 Medline TA: Trends Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 619-28 Citation Subset: IM |
Affiliation:
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Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK. Patrick.Kehoe@bristol.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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drug therapy,
etiology,
genetics,
metabolism* Angiotensin II Type 1 Receptor Blockers / pharmacology, therapeutic use Angiotensin-Converting Enzyme Inhibitors / pharmacology, therapeutic use Angiotensins / drug effects, metabolism* Animals Brain / metabolism, physiopathology Cognition / drug effects Disease Models, Animal Humans Models, Biological Renin-Angiotensin System / drug effects, genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Angiotensins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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