| Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women. | |
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MedLine Citation:
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PMID: 12181363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine whether the M235T angiotensinogen (AGT) polymorphism, either interacting with habitual physical activity (PA) levels or independently, was associated with cardiovascular (CV) hemodynamics during maximal and submaximal exercise. Sixty-one healthy postmenopausal women (16 sedentary, 21 physically active, and 24 endurance athletes) had heart rate (HR), blood pressure (BP), cardiac output, stroke volume (SV), total peripheral resistance (TPR), and arteriovenous O2 difference (a-vDO2) assessed during 40, 60, 80, and approximately 100% of VO2 max treadmill exercise. VO2 max did not differ among AGT genotype groups; however, maximal HR was 14 beats/min higher in AGT TT than MM genotype women (P < 0.05). AGT TT genotype women also had 19 beats/min higher HR during approximately 100% VO2 max exercise than AGT MM genotype women (P = 0.008). AGT genotype also interacted with habitual PA levels to associate with systolic BP and a-vDO2 during approximately 100% VO2 max exercise (both P < 0.01). AGT TT genotype women had 11 beats/min higher HR during submaximal exercise than MM genotype women (P < 0.05). AGT genotype interacted with habitual PA levels to associate with systolic BP during submaximal exercise (P = 0.009). AGT genotype, independently or interacting with habitual PA levels, did not associate significantly with diastolic BP, cardiac output, SV, or TPR during maximal or submaximal exercise. Thus this common genetic variant in the renin-angiotensin system appears to associate, both interactively with habitual PA levels and independently, with HR, systolic BP, and a-vDO2 responses to maximal and submaximal exercise in postmenopausal women. |
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Authors:
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Steve D McCole; Michael D Brown; Geoffrey E Moore; Robert E Ferrell; Kenneth R Wilund; Andrea Huberty; Larry W Douglass; James M Hagberg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2002-08-14 |
Journal Detail:
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Title: Physiological genomics Volume: 10 ISSN: 1531-2267 ISO Abbreviation: Physiol. Genomics Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-15 Completed Date: 2002-09-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: United States |
Other Details:
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Languages: eng Pagination: 63-9 Citation Subset: IM |
Affiliation:
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Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensinogen
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genetics*,
physiology Blood Pressure Cardiac Output / genetics Exercise* Exercise Test Female Gene Frequency Genotype Hemodynamics / genetics*, physiology Humans Oxygen Consumption Polymorphism, Genetic* Postmenopause / genetics*, physiology Stroke Volume |
| Grant Support | |
ID/Acronym/Agency:
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5M01-RR-00056/RR/NCRR NIH HHS; AG-00268/AG/NIA NIH HHS; HL-39107/HL/NHLBI NIH HHS; HL-45778/HL/NHLBI NIH HHS; HL-54526/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11002-13-4/Angiotensinogen |
| Comments/Corrections | |
Comment In:
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Physiol Genomics. 2002 Aug 14;10(2):45-7
[PMID:
12181360
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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