| The angiotensinogen AGT p.M235T gene polymorphism may be responsible for the development of severe anaphylactic reactions to insect venom allergens. | |
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MedLine Citation:
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PMID: 20413984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Insect venom allergy (IVA) is present in 1-3% of the population. A group of patients with high specific IgE do not react to stings. In contrast, a proportion of patients with IVA have low specific IgE levels. These findings indicate that factors other than specific IgE may also be involved in IVA. Dysfunction of the renin-angiotensin system (RAS) has been described as a potential factor in IVA. The objective of this study was to determine the prevalence of angiotensin AGT p.M235T and angiotensin-converting enzyme ACE I/D, I/I, D/D gene polymorphisms in patients with IVA and to relate the presence of these gene variants to the course of IVA and the safety of treatment. METHODS: A total of 107 patients with IVA and 113 controls were studied. AGT p.M235T and ACE (ID, I/I, D/D) gene polymorphisms were examined, and angiotensin I levels were measured by immunoassay. RESULTS: The frequency of the AGT MM M235T variant was significantly higher in IVA patients (29.9%) than in controls (17%, p = 0.02). The presence of the MM M235T genotype increased the risk of grade IV reactions (odds ratio = 2.5 and 95% confidence interval 1.04-6.08). There were no differences in the prevalence of the ACE I/D polymorphism and angiotensin I levels between control groups and patients with different grades of anaphylactic reactions or patients with side effects of venom immunotherapy. CONCLUSION: The AGT M235T MM variant may be responsible for severe anaphylactic reactions to insect venom allergens in some patients. |
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Authors:
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Marek Niedoszytko; Magdalena Ratajska; Marta Chełmińska; Michał Makowiecki; Ewelina Malek; Alicja Siemińska; Janusz Limon; Ewa Jassem |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-22 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 153 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 166-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Allergology, Medical University of Gdansk, Poland. mnied@amg.gda.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Allergens / immunology* Anaphylaxis / etiology, genetics* Angiotensin I / blood Angiotensinogen / genetics* Animals Arthropod Venoms / immunology* Bee Venoms Female Humans Hymenoptera / immunology* Male Middle Aged Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Arthropod Venoms; 0/Bee Venoms; 11002-13-4/Angiotensinogen; 9041-90-1/Angiotensin I; EC 3.4.15.1/Peptidyl-Dipeptidase A |
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