Document Detail


The angiotensinogen AGT p.M235T gene polymorphism may be responsible for the development of severe anaphylactic reactions to insect venom allergens.
MedLine Citation:
PMID:  20413984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Insect venom allergy (IVA) is present in 1-3% of the population. A group of patients with high specific IgE do not react to stings. In contrast, a proportion of patients with IVA have low specific IgE levels. These findings indicate that factors other than specific IgE may also be involved in IVA. Dysfunction of the renin-angiotensin system (RAS) has been described as a potential factor in IVA. The objective of this study was to determine the prevalence of angiotensin AGT p.M235T and angiotensin-converting enzyme ACE I/D, I/I, D/D gene polymorphisms in patients with IVA and to relate the presence of these gene variants to the course of IVA and the safety of treatment. METHODS: A total of 107 patients with IVA and 113 controls were studied. AGT p.M235T and ACE (ID, I/I, D/D) gene polymorphisms were examined, and angiotensin I levels were measured by immunoassay. RESULTS: The frequency of the AGT MM M235T variant was significantly higher in IVA patients (29.9%) than in controls (17%, p = 0.02). The presence of the MM M235T genotype increased the risk of grade IV reactions (odds ratio = 2.5 and 95% confidence interval 1.04-6.08). There were no differences in the prevalence of the ACE I/D polymorphism and angiotensin I levels between control groups and patients with different grades of anaphylactic reactions or patients with side effects of venom immunotherapy. CONCLUSION: The AGT M235T MM variant may be responsible for severe anaphylactic reactions to insect venom allergens in some patients.
Authors:
Marek Niedoszytko; Magdalena Ratajska; Marta Chełmińska; Michał Makowiecki; Ewelina Malek; Alicja Siemińska; Janusz Limon; Ewa Jassem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-22
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  153     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-17     Completed Date:  2010-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Department of Allergology, Medical University of Gdansk, Poland. mnied@amg.gda.pl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Allergens / immunology*
Anaphylaxis / etiology,  genetics*
Angiotensin I / blood
Angiotensinogen / genetics*
Animals
Arthropod Venoms / immunology*
Bee Venoms
Female
Humans
Hymenoptera / immunology*
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/Allergens; 0/Arthropod Venoms; 0/Bee Venoms; 11002-13-4/Angiotensinogen; 9041-90-1/Angiotensin I; EC 3.4.15.1/Peptidyl-Dipeptidase A

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