Document Detail

Angiotensin synthesis in the brain and increased turnover in hypertensive rats.
MedLine Citation:
PMID:  6879184     Owner:  NLM     Status:  MEDLINE    
The missing link in the evidence for an active endogenous renin angiotensin system in the brain has been the demonstration of local angiotensin synthesis in the central nervous system in vivo. In this report the extraction and characterization of angiotensin I and angiotensin II from the brain of rats is described. The accumulation of angiotensin I was enhanced in hypertensive rats when the conversion to angiotensin II was blocked in vivo by the converting enzyme inhibitor captopril.
D Ganten; K Hermann; C Bayer; T Unger; R E Lang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  221     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  869-71     Citation Subset:  IM    
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MeSH Terms
Angiotensin I / cerebrospinal fluid
Angiotensin II / biosynthesis
Angiotensinogen / metabolism
Angiotensins / biosynthesis*
Brain / metabolism*
Hypertension / metabolism*
Reg. No./Substance:
0/Angiotensins; 11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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