| Angiotensin receptors as determinants of life span. | |
| | |
MedLine Citation:
|
PMID: 19763608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Angiotensin II (Ang II), the central product of renin-angiotensin system, has a role in the etiology of hypertension and in pathophysiology of cardiac and renal diseases in humans. Other functions of Ang II include effects on immune response, inflammation, cell growth and proliferation, which are largely mediated by Ang II type 1 receptor (AT(1)). Several experimental studies have demonstrated that Ang II acts through AT(1) as a mediator of normal aging processes by increasing oxidant damage to mitochondria and in consequences by affecting mitochondrial function. Recently, our group has demonstrated that the inhibition of Ang II activity by targeted disruption of the Agtr1a gene encoding Ang II type 1A receptor (AT(1A)) in mice translates into marked prolongation of life span. The absence of AT(1A) protected multiple organs from oxidative damage and the alleviation of aging-like phenotype was associated with increased number of mitochondria and upregulation of the prosurvival gene sirtuin 3. AT(1) receptor antagonists have been proven safe and well-tolerated for chronic use and are used as a key component of the modern therapy for hypertension and cardiac failure, therefore Ang II/AT(1) pathway represents a feasible therapeutic strategy to prolong life span in humans. |
| | |
Authors:
|
Paola Cassis; Sara Conti; Giuseppe Remuzzi; Ariela Benigni |
Related Documents
:
|
22461768 - Co-release of gaba does not occur at glycinergic synapses onto lumbar motoneurons in ju... 1492128 - Sensitivity increase in the photophobic response of halobacterium halobium reconstitute... 8756008 - Angiotensin ii type 2 receptor-mediated regulation of rat neuronal k+ channels. 9305468 - Losartan improves the performance of ethanol-intoxicated rats in an eight-arm radial maze. 21666748 - Antidepressant drugs transactivate trkb neurotrophin receptors in the adult rodent brai... 2844358 - Two pharmacologically distinct receptors mediate two postsynaptic potential (psp) compo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-09-11 |
Journal Detail:
|
Title: Pfl?gers Archiv : European journal of physiology Volume: 459 ISSN: 1432-2013 ISO Abbreviation: Pflugers Arch. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-21 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
|
Languages: eng Pagination: 325-32 Citation Subset: IM |
Affiliation:
|
Mario Negri Institute for Pharmacological Research, Via Gavazzeni, 11, 24125 Bergamo, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
drug effects,
physiology* Angiotensin II / physiology* Angiotensin-Converting Enzyme Inhibitors / therapeutic use Animals Humans Longevity / physiology* Mitochondria / physiology Oxidative Stress / physiology Receptors, Angiotensin / antagonists & inhibitors, physiology* Renin-Angiotensin System / physiology Sirtuin 3 / physiology Sirtuins / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; EC 3.5.1.-/Sirtuin 3; EC 3.5.1.-/Sirtuins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gene variants as determinants of longevity: focus on the inflammatory factors.
Next Document: Senescence and life span.