Document Detail


Angiotensin receptor subtypes in rat, rabbit and monkey tissues: relative distribution and species dependency.
MedLine Citation:
PMID:  1943452     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The displacement of [125I]Sar1, Ile8 angiotensin II binding by the receptor subtype selective angiotensin II antagonists, DuP-753 and WL-19 (PD121981) was used to define the relative proportion of angiotensin subtype AT1 and subtype AT2 receptors, respectively in various tissues (aorta, heart, adrenal cortex, kidney cortex and brain) of the rat, rabbit and monkey. The relative abundance of these receptor subtypes varied greatly not only among different tissues of the same species but also within the same tissue of different species. The relative affinity of the DuP-753 and WL-19 for the angiotensin receptor subtypes did not vary markedly suggesting that the two angiotensin receptor subtypes in these tissues and species are similar.
Authors:
R S Chang; V J Lotti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  49     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-13     Completed Date:  1991-12-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1485-90     Citation Subset:  IM    
Affiliation:
Department of New Lead Pharmacology, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex / metabolism
Angiotensin II / analogs & derivatives,  antagonists & inhibitors,  metabolism
Animals
Aorta / metabolism
Brain / metabolism
Enzyme Inhibitors / metabolism
Kidney Cortex / metabolism
Macaca
Myocardium / metabolism
Rabbits
Rats
Receptors, Angiotensin / classification,  metabolism*
Species Specificity
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 51833-69-3/angiotensin II, Sar(1)-Ile(5)-

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