| Angiotensin mediated interaction of fetal kidney and placenta in the control of fetal arterial pressure and its role in hydrops fetalis. | |
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MedLine Citation:
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PMID: 9179925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal cardiovascular control is effected by an interaction of the fetal somatic and placental circulations. Three primary regulatory mechanisms are involved: transplacental transfer of extracellular fluid, driven by a difference in hydrostatic and oncotic pressures; modulation of fetal placental and somatic vascular resistances by means of blood pressure controlled production of angiotensin; and somatic autoregulation of flow. A systems analysis incorporates these and other fetal cardiovascular functions and this analysis was modelled for computer simulation. Given physiologically plausible values for known cardiovascular parameters in the fetal sheep, the model reproduced in detail a variety of experimental protocols with known outcomes; these included the normal fetus, the fetus after bilateral nephrectomy, the nephrectomized fetus infused with angiotensin, the intact fetus infused with NaCl solutions, the fetus with lymphatic obstruction and the severely anaemic fetus. The systems analysis demonstrated that fetal cardiac failure constituted the strongest stimulus for the formation of fetal oedema of any tested pathological intervention. |
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Authors:
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J J Faber; D F Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Placenta Volume: 18 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-17 Completed Date: 1997-07-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 313-26 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Portland 97201-3098, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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physiology* Animals Blood Pressure* Fetal Diseases / physiopathology Fetus / physiology* Humans Hydrops Fetalis / physiopathology* Kidney / embryology* Nephrectomy Placenta / blood supply, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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HD-28965/HD/NICHD NIH HHS; HL-42893/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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