| Angiotensin ii receptor type 1 1166 a/c and angiotensin converting enzyme I/D gene polymorphisms in a Dutch sarcoidosis cohort. | |
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MedLine Citation:
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PMID: 21319597 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The angiotensin II type 1 receptor (AT2R1) is the receptor for angiotensin II, a potent vasoconstrictor produced by ACE from angiotensin I. A recent study by Biller and colleagues revealed a gender-specific association between the AT2R1 1166 A/C gene polymorphism and disease susceptibility as well as a co-dependent association between AT2R1 1166 A/C and the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism on ACE levels in a group of German sarcoidosis patients. OBJECTIVE: . The aim of our study was to compare our results from Dutch Caucasian sarcoidosis patients with the results of Biller et al. DESIGN: Serum and DNA from 99 patients with sarcoidosis and from 327 healthy controls were included. The AT2R1 1166 A/C and ACE I/D polymorphisms and serum ACE levels were analyzed in all subjects. RESULTS: No significant differences were found between the genotype distributions between the sarcoidosis patients and controls. The genotype distributions for either polymorphism between genders and between patients with progressive/chronic disease and those with acute/remission type disease were not different. The ACE D allele contributed significantly to higher ACE levels. This was true for both sarcoidosis patients and controls. There was no association between the AT2R1 1166 A/C genotype and ACE levels, nor did AT2R1 modify the ACE D/I effects on ACE levels. No significant differences were observed in co-incidence of ACE and AT2R1 genotypes between patients and controls. CONCLUSION: Our study could not confirm the findings by Biller and colleagues other than the influence of the ACE I/D polymorphism on serum ACE levels in both sarcoidosis patients and controls. |
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Authors:
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A Kruit; H J T Ruven; J C Grutters; J M van den Bosch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders Volume: 27 ISSN: 1124-0490 ISO Abbreviation: Sarcoidosis Vasc Diffuse Lung Dis Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610928 Medline TA: Sarcoidosis Vasc Diffuse Lung Dis Country: Italy |
Other Details:
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Languages: eng Pagination: 147-52 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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