Document Detail


Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension.
MedLine Citation:
PMID:  15447944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism influences ACE activity, cardiovascular risk, blood pressure, and possibly the risk of developing Alzheimer's dementia. We explored the association of the insertion/deletion polymorphism with sleep-disordered breathing (SDB) and hypertension in 1,100 subjects of the Wisconsin Sleep Cohort. The polymorphism did not influence body mass index or the occurrence of SDB, but was dose-dependently associated with blood pressure. Interestingly, SDB and the insertion/deletion polymorphism interacted significantly to modulate blood pressure independently of age, sex, ethnicity, and body mass index. Most specifically, the association of the deletion allele with hypertension was most pronounced in subjects with mild to moderate degrees of sleep apnea (5 < or = apnea-hypopnea index < or = 30). We hypothesize that in the absence of SDB the effect of the deletion allele alone may not be sufficient to increase blood pressure. At severe levels of SDB, the effect of sleep apnea on blood pressure overwhelms any association of the deletion allele with hypertension and occurs independent of any ACE gene genotype.
Authors:
Ling Lin; Laurel Finn; Jing Zhang; Terry Young; Emmanuel Mignot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2004-09-24
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  170     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1349-53     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304-5742, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Gene Deletion
Humans
Hypertension / genetics*
Male
Middle Aged
Mutagenesis, Insertional
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Sleep Apnea Syndromes / genetics*
Grant Support
ID/Acronym/Agency:
AG14124/AG/NIA NIH HHS; HL071515/HL/NHLBI NIH HHS; HL62252/HL/NHLBI NIH HHS; NS23724/NS/NINDS NIH HHS; RR03186/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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