Document Detail


Angiotensin-converting enzyme and the renin-angiotensin system in normotensive primigravid pregnancy.
MedLine Citation:
PMID:  6307553     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a prospective study the interactions between ACE and the renin-angiotensin system in 18 primigravid normotensive women were investigated throughout pregnancy. ACE activity was found to be depressed throughout pregnancy, rising in the last trimester and returning to non-pregnant values by 6 weeks post partum. No significant differences were found between cord arterial or venous and maternal venous ACE levels at delivery. ACE was inversely related to systolic and mean arterial blood pressures, inversely to serum sodium and urinary potassium and directly to serum potassium levels. Within the system, ACE was correlated only to aldosterone levels. In company with other components of the system ACE activity appears to be altered in pregnancy and to be influenced by similar control mechanisms. It is possible that ACE plays a modulating role on aldosterone secretion via the (des-asp1), Angiotensin I pathway.
Authors:
J N Oats; F Broughton Pipkin; E M Symonds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension. Part B, Hypertension in pregnancy     Volume:  1     ISSN:  0730-0085     ISO Abbreviation:  Clin Exp Hypertens B     Publication Date:  1982  
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2008-03-04    
Medline Journal Info:
Nlm Unique ID:  8207433     Medline TA:  Clin Exp Hypertens B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Blood Cell Count
Blood Pressure*
Body Weight
Female
Fetal Blood / chemistry
Humans
Infant, Newborn
Kidney Function Tests
Parity*
Peptidyl-Dipeptidase A / blood*,  physiology
Potassium / blood,  urine
Pregnancy
Prospective Studies
Renin / blood
Renin-Angiotensin System*
Sodium / blood,  urine
Chemical
Reg. No./Substance:
7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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