| Angiotensin-converting enzyme inhibitors reduce long-term aortic events in patients with acute type B aortic dissection. | |
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MedLine Citation:
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PMID: 18827369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Medical therapy gives excellent short-term outcomes for patients with Stanford type B acute aortic dissection. However, the affected aorta is often compromised by aneurysmal dilatation and rupture, resulting in poor long-term outcome. The present study investigated which antihypertensive treatment may prevent long-term aortic events in these patients. METHODS AND RESULTS: The study group comprised 78 consecutive patients with Stanford type B acute aortic dissection who were treated medically and followed-up for an average of 873+/-548 days. The optimal hypertensive drug regimen to reduce aortic events was determined by multivariate analyses. Of the 78 patients, 73 (94%) were discharged from hospital with medical therapy, and aortic events occurred in 13 (18%) of them (aortic rupture/recurrent dissection in 2 (3%); aortic expansion >or=60 mm in 7 (10%), rapid aortic expansion >or=10 mm/year in 3 (4%), and development of visceral/limb ischemia in 1 (1%)) during follow-up. By multivariate analysis, patients given angiotensin-converting enzyme inhibitor (ACEI) were less likely to have long-term aortic events than those without (odds ratio: 0.18, 95% confidence interval: 0.04-0.85). CONCLUSIONS: Use of ACEI is associated with a reduced risk of long-term aortic events in patients with medically treated type B aortic dissection. |
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Authors:
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Satoshi Takeshita; Shingo Sakamoto; Shuichi Kitada; Koichi Akutsu; Hideki Hashimoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-29 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-24 Completed Date: 2008-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1758-61 Citation Subset: IM |
Affiliation:
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Department of Cardiology, National Cardiovascular Center, Suita, Japan. stake@muse.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors / administration & dosage* Aortic Rupture / mortality*, therapy* Disease-Free Survival Female Follow-Up Studies Humans Male Middle Aged Survival Rate Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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