Document Detail

Angiotensin-converting enzyme inhibitors and change in aortic valve calcium.
MedLine Citation:
PMID:  15851635     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Calcium accumulation in the aortic valve is a hallmark of aortic sclerosis and aortic stenosis. Because lipoproteins, angiotensin-converting enzyme, and angiotensin II colocalize with calcium in aortic valve lesions, we hypothesized an association between angiotensin-converting enzyme inhibitor (ACEI) use and lowered aortic valve calcium (AVC) accumulation, as measured by electron beam computed tomography. METHODS: Rates of change in volumetric AVC scores were determined retrospectively for 123 patients who had undergone 2 serial electron beam computed tomographic scans. The mean (+/-SD) interscan interval was 2.5 (+/-1.7) years; 80 patients did not receive ACEIs and 43 received ACEIs. The relationship of ACEI use to median rates of AVC score change (both unadjusted and adjusted for baseline AVC scores and coronary heart disease risk factors) was determined. We also examined the relationship of ACEI use to the likelihood of and adjusted odds ratio for definite progression (AVC change >2 times the median interscan variability). RESULTS: Unadjusted and adjusted median rates of AVC score change were significantly higher in the no-ACEI group than in the ACEI group (adjusted median AVC changes [95% confidence interval]: relative, 28.7%/y [18.9%-38.5%/y] vs 11.0%/y [-1.9% to 24.0%/y], P = .04; absolute: 25.1/y [19.7-30.5/y] vs 12.2/y [4.5-19.9/y], P = .02). The adjusted odds ratio (95% confidence interval) for definite AVC progression was significantly lower for patients who received ACEIs (0.29 [0.11-0.75], P = .01). CONCLUSIONS: This retrospective study finds a significant association between ACEI use and a lower rate of AVC accumulation. The results support the need for prospective, randomized trials of ACEIs in calcific aortic valve disease.
Kevin D O'Brien; Jeffrey L Probstfield; Michael T Caulfield; Khurram Nasir; Junichiro Takasu; David M Shavelle; Audrey H Wu; Xue-Qiao Zhao; Matthew J Budoff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of internal medicine     Volume:  165     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  858-62     Citation Subset:  AIM; IM    
Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Aortic Valve / metabolism*,  radiography
Aortic Valve Stenosis / etiology,  metabolism,  prevention & control
Calcinosis / metabolism,  prevention & control*,  radiography
Calcium / metabolism*
Follow-Up Studies
Hypertension / drug therapy
Regression Analysis
Retrospective Studies
Risk Factors
Tomography, X-Ray Computed
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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