| Angiotensin-converting enzyme inhibitor suppresses activation of calcineurin in renovascular hypertensive rats. | |
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MedLine Citation:
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PMID: 18344631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence suggests an important role of the calcineurin signaling pathway in mediating the development of cardiac hypertrophy. It has also been reported that angiotensin-converting enzyme inhibitors (ACEIs) regressed cardiac hypertrophy in some animal and human models. In this study, we investigated the possible role of calcineurin in the regression of cardiac hypertrophy induced by the ACEI perindopril in rats with renovascular hypertension. The effect of the calcineurin inhibitor cyclosporine A (CsA) was also studied. Starting from 2 months after a two-kidney one-clip (2K1C) procedure, the rats that had developed progressive left ventricular (LV) hypertrophy were daily administered perindopril (1 mg/kg per day) or CsA (20 mg/kg per day) until 3 months. At the end of either treatment, the LV gravimetric, morphometric and histological measurements revealed the regression of LV hypertrophy; and the enzymatic assay, Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) showed that both calcineurin activity and the calcineurin protein and mRNA expression levels were significantly decreased compared with untreated 2K1C rats, but that LV systolic performance was unchanged by either treatment. These data suggest that the cardiac hypertrophy regression induced by the ACEI perindopril is likely mediated, at least in part, through inhibition of the calcineurin signaling pathway. |
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Authors:
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Hongzhuan Sheng; Jianhua Zhu; Xiaohui Wu; Di Yang; Jinan Zhang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 30 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-03-17 Completed Date: 2008-04-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 1247-54 Citation Subset: IM |
Affiliation:
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Department of Cardiology, The Affiliated Hospital of Nantong University, Nantong, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Animals Blood Pressure / drug effects Calcineurin / antagonists & inhibitors, metabolism* Cyclosporine / pharmacology Heart Ventricles / metabolism, pathology Hypertension, Renovascular / complications, metabolism* Hypertrophy, Left Ventricular / etiology, metabolism, prevention & control Male Perindopril / pharmacology* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Renin-Angiotensin System / drug effects Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/RNA, Messenger; 59865-13-3/Cyclosporine; 82834-16-0/Perindopril; EC 3.1.3.16/Calcineurin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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